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9/10 Dog Parents Reported An Improvement In Their Dog's Mobility
Crafted with love and backed by science, our treats boast a potent blend of ingredients like glucosamine, chondroitin, MSM, and green-lipped mussel. These elements work in harmony to nurture joint health, support cartilage regeneration and provide relief from the discomfort your furry companion might be silently enduring. This isn't just our promise – it's a shared experience. A whopping 90% of dog owners have seen incredible improvements in their canine friend's mobility.
These statements have not been evaluated by the Food and Drug Administration. These products are not
intended to diagnose, treat, cure, or prevent any disease or health condition.
- Perna, glucosamine, MSM, DMG, and antioxidants for advanced joint support in canines. Greenfield Animal Hospital. (n.d.). Retrieved from https://greenfieldvets.com/
- Perna: VCA Animal Hospital. Vca. (n.d.). Retrieved from https://vcahospitals.com/know-your-pet/perna#:~:text=What%20is%20perna%3F,cats%2C%20dogs%2C%20and%20horses.
- Kim, L. S., Axelrod, L. J., Howard, P., Buratovich, N., & Waters , R. F. (n.d.). Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: A pilot clinical trial. Osteoarthritis and cartilage. Retrieved from https://pubmed.ncbi.nlm.nih.gov/16309928/
- Bhathal, A., Spryszak, M., Louizos, C., & Frankel, G. (2017). Glucosamine and chondroitin use in canines for osteoarthritis: A Review. Open veterinary journal. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356289/
- Bierer, T. L., & Bui, L. M. (2002, June 1). Improvement of arthritic signs in dogs fed green-lipped mussel (Perna canaliculus). OUP Academic. Retrieved from https://academic.oup.com/jn/article/132/6/1634S/4687864
- Debbi, E. M., Agar, G., Fichman, G., Ziv, Y. B., Kardosh, R., Halperin, N., Elbaz, A., Beer, Y., & Debi, R. (2011, June 27). Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: A randomized controlled study. BMC complementary and alternative medicine. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141601/
- Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017, March 16). Methylsulfonylmethane: Applications and safety of a novel dietary supplement. Nutrients. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372953/
- Kabil O, Vitvitsky V, Banerjee R. Sulfur as a signaling nutrient through hydrogen sulfide. Annu Rev Nutr. 2014;34:171-205. doi: 10.1146/annurev-nutr-071813-105654. PMID: 25033061; PMCID: PMC4684266. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684266/
- Whitehouse, M. W., Macrides, T. A., Kalafatis, N., Betts, W. H., Haynes, D. R., & Broadbent, J. (1997). Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel. Inflammopharmacology, 5(3), 237–246. https://doi.org/10.1007/s10787-997-0002-0
These statements have not been evaluated by the Food and Drug Administration. These products are not
intended to diagnose, treat, cure, or prevent any disease or health condition.
- Perna, glucosamine, MSM, DMG, and antioxidants for advanced joint support in canines. Greenfield Animal Hospital. (n.d.). Retrieved from https://greenfieldvets.com/
- Perna: VCA Animal Hospital. Vca. (n.d.). Retrieved from https://vcahospitals.com/know-your-pet/perna#:~:text=What%20is%20perna%3F,cats%2C%20dogs%2C%20and%20horses.
- Kim, L. S., Axelrod, L. J., Howard, P., Buratovich, N., & Waters , R. F. (n.d.). Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: A pilot clinical trial. Osteoarthritis and cartilage. Retrieved from https://pubmed.ncbi.nlm.nih.gov/16309928/
- Bhathal, A., Spryszak, M., Louizos, C., & Frankel, G. (2017). Glucosamine and chondroitin use in canines for osteoarthritis: A Review. Open veterinary journal. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356289/
- Bierer, T. L., & Bui, L. M. (2002, June 1). Improvement of arthritic signs in dogs fed green-lipped mussel (Perna canaliculus). OUP Academic. Retrieved from https://academic.oup.com/jn/article/132/6/1634S/4687864
- Debbi, E. M., Agar, G., Fichman, G., Ziv, Y. B., Kardosh, R., Halperin, N., Elbaz, A., Beer, Y., & Debi, R. (2011, June 27). Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: A randomized controlled study. BMC complementary and alternative medicine. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141601/
- Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017, March 16). Methylsulfonylmethane: Applications and safety of a novel dietary supplement. Nutrients. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372953/
- Kabil O, Vitvitsky V, Banerjee R. Sulfur as a signaling nutrient through hydrogen sulfide. Annu Rev Nutr. 2014;34:171-205. doi: 10.1146/annurev-nutr-071813-105654. PMID: 25033061; PMCID: PMC4684266. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684266/
- Whitehouse, M. W., Macrides, T. A., Kalafatis, N., Betts, W. H., Haynes, D. R., & Broadbent, J. (1997). Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel. Inflammopharmacology, 5(3), 237–246. https://doi.org/10.1007/s10787-997-0002-0
As Featured In..
Did you know? A staggering 80% of
dogs over 8 develop joint issues!
While other dog joint supplements mainly use Omega-3s, they lack the extra hydration provided by Perna
Canaliculus.
Perna is a Green-lipped mussel from the shores of New Zealand, 100x+ more powerful than Omega-3 alone. It is naturally rich in Glucosamine, Chondroitin, Hyaluronic acid, EFAs, and Amino acids – a perfect blend for not just healing but also for joint issue prevention.
Let's look at some simple visual comparisons to see how effective our Perna Canaliculus formula is:
Perna is a Green-lipped mussel from the shores of New Zealand, 100x+ more powerful than Omega-3 alone. It is naturally rich in Glucosamine, Chondroitin, Hyaluronic acid, EFAs, and Amino acids – a perfect blend for not just healing but also for joint issue prevention.
Let's look at some simple visual comparisons to see how effective our Perna Canaliculus formula is:
Damaged Cartilage
The deterioration of this vital cushioning tissue can lead to pain, restricted joint movement, and
general discomfort
Loosen Ligament
As dogs age, the collagen and connective tissues in their joints may undergo changes, leading to
reduced elasticity and firmness in the ligaments.
Synovial Inflammation
Aging can lead to a reduction in lubrication, which may result in less production of synovial fluid
and increased friction within the joint.
Ligament
Perna supports optimal joint hydration, which promotes the elasticity and strength of ligaments,
therefore reducing the risk of strain and injury.
Cartilage
Our powerful blend of ingredients, including glucosamine and chondroitin, aids in the reconstruction
of damaged cartilage.
Synovium
Our formula has anti-inflammatory and highly lubricant properties that reduce inflammation in the
synovium and improve mobility.
Easily Digestible Ingredients
Nothing to hide here! Our recipe is suitable for even sensitive stomachs.
Picture-Perfect Moments From Our Customers
Why Keep Your Pups Waiting?
Give them the Gift of Health and Mobility with PupGrade!
Your guarantee for extra happiness and a longer journey together.
Our delicious chews are not only a treat your dog will adore, but they're also loaded with the perfect
balance of nutrients to maintain their joints and hips in optimal condition, including: Glucosamine,
Chondroitin, MSM, and Perna Canaliculus — all vital for supporting joint health.
Happy Joints, Happy Dogs
Words from those who've transformed their dogs' lives with PupGrade
Feeding Recommendations
Suitable for dogs across breeds, sizes, and ages, PupGrade Joint Chews serve as a delightful treat during
or after meals.
Suggested use by weight:
30 lbs
1 chew per day
60 lbs
2 chews per day
90 lb
3 chews per day
120 lbs
4 chews per day
150 lbs
5 chews per day
Frequently Asked Questions
Find the answers you need right here
WHAT IS PUPGRADE JOINT SUPPORT FOR? DOES IT HAVE THE CORRECT DOSAGE FOR MY DOG’S NEEDS?
PupGrade Joint Support is a chewable supplement for dogs and puppies of all breeds, sizes, ages, and activity
levels. Suitable for everyday canine health.
Our Joint Support is a research-backed formula with just the right amount of essential nutrients to help keep your pup mobile and lively.
Our Joint Support is a research-backed formula with just the right amount of essential nutrients to help keep your pup mobile and lively.
HOW DO I FEED THIS SUPPLEMENT TO MY DOG?
We recommend following these directions for use:
1 Chew:
per 25 lbs.
Extra Support:
double dosage first 4 weeks.
1 Chew Daily:
divide between AM & PM.
*This product is intended for intermittent or supplemental feeding only.
1 Chew:
per 25 lbs.
Extra Support:
double dosage first 4 weeks.
1 Chew Daily:
divide between AM & PM.
*This product is intended for intermittent or supplemental feeding only.
IS THIS SUPPLEMENT FREE OF GRAIN?
We are a veterinarian-formulated brand you can trust. These chews are made with only the good stuff and are 100%
junk-free! We are proud to offer your pet savory, GMP-Certified chews free of grains, wheat, corn, artificial
colors, dyes, or harmful preservatives.
HOW MANY CHEWS ARE IN THIS CONTAINER?
Our Joint Support supplements offer 60 chews per container.
WHAT ARE THE INGREDIENTS INCLUDED IN THIS PRODUCT?
Active Ingredients:
Glucosamine, Methyl Sulfonyl Methane, Green Lipped Mussel, Chondroitin, and Manganese Gluconate.
Additional Ingredients:
Brewer’s Yeast, Potato Flour, Can Molasses, Potato Starch, Purified Water, Soy Lecithin, Glycerin, Cooked Beef, Safflower Oil, Duck Flavor, Vitamin E, Ascorbic Acid, Sorbic Acid, Mixed Tocopherols.
Glucosamine, Methyl Sulfonyl Methane, Green Lipped Mussel, Chondroitin, and Manganese Gluconate.
Additional Ingredients:
Brewer’s Yeast, Potato Flour, Can Molasses, Potato Starch, Purified Water, Soy Lecithin, Glycerin, Cooked Beef, Safflower Oil, Duck Flavor, Vitamin E, Ascorbic Acid, Sorbic Acid, Mixed Tocopherols.
WHAT IS THE GUARANTEED ANALYSIS PER CHEW (5g)?
Calories:
18 Kcal
Crude Protein (Min):
18%
Crude Fat (Min):
12%
Crude Fiber (Max):
3%
Moisture (Max):
8%
18 Kcal
Crude Protein (Min):
18%
Crude Fat (Min):
12%
Crude Fiber (Max):
3%
Moisture (Max):
8%
ARE THESE CHEWS SAFE FOR MY DOG IF THEY HAVE SENSITIVITIES OR OTHER CONDITIONS?
We understand that every dog has unique needs. That’s why we offer supplements tailored to address specific
concerns, such as sensitive stomachs and diabetic conditions. Our supplements contain easily digestible
ingredients and exclude common allergens. Consult with your veterinarian before giving this supplement to your dog
if you have any concerns.
HOW DO I STORE THIS PRODUCT?
Store in a cool, dry place. Ensure container lid is securely closed after each use.